FARMAK, a.s. focused on nuclear magnetic resonance in the study of small molecules

01. 06. 2023

Nuclear magnetic resonance spectroscopy (NMR) is a powerful analytical tool used in API (active pharmaceutical ingredient) research and development by pharmaceutical companies worldwide. FARMAK, a.s., specializing in the production of so-called "generic" APIs, uses NMR technology to study the chemical and physical properties of small molecules.

How does nuclear magnetic resonance spectroscopy work?

Nuclear magnetic resonance spectroscopy works by detecting magnetic fields produced by atomic nuclei in a magnetic field. When a sample is exposed to a magnetic field and a high-frequency pulse, the nuclei absorb and emit energy, creating a unique spectral signature that can be used to determine the chemical structure of the sample.

Nuclear magnetic resonance is a non-destructive technique and can provide both qualitative and quantitative information about a sample.

Picture 1: Description of how NRM works (1)

What can nuclear magnetic resonance spectroscopy be used for?
FARMAK, a.s. uses NMR to research and develop new ways to prepare generic APIs. "It can also be used to ensure product quality and purity, to identify impurities and contaminants, and to confirm the identity and structural integrity of APIs," describes Director of Research and Strategy Roman Buchtík, Ph.D. "We can also use this method to study the stability of APIs under different conditions such as temperature, humidity and exposure to light," adds Roman Buchtík.

FARMAK, a.s. sees the importance of sharing information and discovery in the field of nuclear magnetic resonance spectroscopy.

FARMAK, a.s. invested in this technology years ago and has a team of experienced NMR scientists who work closely with other teams in API research and development. The company has also established partnerships with academic institutions (including UPOL and UPCE) and other pharmaceutical companies to share expertise in this area.

Nuclear magnetic resonance spectroscopy is a vital tool for pharmaceutical companies in the research and development of new molecules. "NMR can provide valuable information on quality, purity and stability," concludes Roman Buchtík. With advances in spectroscopy, it is likely that this technique will continue to play a vital role in the pharmaceutical industry for many years to come.

Picture 2 NMR laboratory of FARMAK

(1) https://chembam.com/definitions/nmr/